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If you become pregnant while taking clozaril, do not stop taking it without your doctor s advice.

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12.5 mg once or twice on the first dayfollowed by 25 mg once or twice on the second dayIf well toleratedthe daily dose may then be increased slowly in increments of 25 to 50 mg in order to achieve a dose level of up to 300 mg/day within 2 to 3 weeksThereafterif requiredthe daily dose may be further increased in increments of 50 to 100 mg at half-weekly orpreferablyweekly intervals.

Treatment must be discontinued immediately in the event of neutropenia or agranulocytosissee section 4.4In this situationcareful psychiatric monitoring of the patient is essential since symptoms may recur quickly.

In whom regular white blood cellWBCcounts and absolute neutrophil countsANCcan be performed as followsweekly during the first 18 weeks of treatmentand at least every 4 weeks thereafter throughout treatmentMonitoring must continue throughout treatment and for 4 weeks after complete discontinuation of Clozarilsee section 4.4

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use clozaril cautiously in patients with cardiovascular disease history of myocardialinfarction or ischemia, heart failure, or conduction abnormalities , cerebrovascular disease, and conditions which would predispose patients to hypotension e.