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Yes methylprednisolone or other steroid can cause elevation of blood glucose, with effect lasting up to one week after the last dose.

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Information about Prednisolone.

Prednisolone is an active ingredient that belongs to a group of medicines called corticosteroidsCorticosteroids are synthetic versions of cortisolTo get prednisoloneyou must have a prescription written for you by a doctor.

The rationale for this treatment schedule is based on two major premisesathe anti-inflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects andbadministration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenalHPAactivity on the off-steroid day.

To make sure prednisolone is safe for youtell your doctor if you have ever had:

It’s best to take prednisolone as a single dose once a day straight after breakfastFor exampleif your dose is 40mg dailyit’s usual to take 8 tablets8 x 5mgall at the same time.

Common side effects happen in more than 1 in 100 peopleKeep taking the medicinebut tell your doctor if they bother you or don’t go away:

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snijders suggested that the association of prednisolone therapy in cap with late failures may be due to a rebound effect that could be precipitated by the abrupt withdrawal of the therapy.